????λ?????? > ?????? > ?????? > ??????W > ??????

??????

?????????????????????????

?????????W?? Zh?? Y??

?????????Medcinal Evodia Fruit, Fruit of Medicinal Evodia

???????????????????????????????????????????????????

???????

????????????????????????????????????δ?????????

????????????????1.Evodia rutaecarpa ??Juss.??Benth.2.Evodia rutaecarpa ??Juss.??Benth.var.officinalis ??Dode??Huang3.Evodia rutaecarpa ??Juss.??Benth.var.bodinieri ??Dode??Huang

????????????3?????????7??????????????8???????????????????????δ??????????????δ??????????????????????????????????????????????????????????????ɡ?

????????

1.?????? ????????С???????3-10m????????????????????????С??ε???????????????????????????????????????????????????20-40cm???????4-8cm??С?????2-5mm??С?5-9????????????Σ???5.5-15cm????3-7cm?????????????????Ш??????Ш?λ???Σ??????в??????????????????????????????????????????????????????????????????????????????ɡ??????????????????????????????????????????С???????С???????2??????5???????Σ????1-2mm???????????????5???????????Σ???4-6mm???????5???????????С????????????????????Σ??????????????????????4-5????????????????????????????????????λ??????Σ????5???????????????Σ??д????????????????????4-5????????????Σ???????????5?????????u?????????????????д?????????????????1??????????й??????6-8???????9-10???

2.??? ??????????????????????????????????????????ζ??С?3-11????????????????????????Σ?????????????С?????????????????????????????????????????????????????????????????????????????????????????????????????????????????7-8???????9-10???

3. ????????? ???????????С?????????????????賤?????????????С?5-11????α仯??????Ρ??????Ρ?????????Σ??????????????????????????????????????????????????С??????7-8???????9-10???

???????????

?????????1.???????????????????????????????

2.??????????С?

3.??????·?????????С?

????????1.????????????????????????????????塢????????????????????????????????????

2.??????????????????????????????????????????

3.??????????????????????????????

??????

????????? ?????????????????????????????????????????????????????????????????????????????????????????????

?????? ?????????????己??????????????????????????????????????????????????м??????????????????????????????????3?????-4????????????巨?????о?15-20cm??????????3-5cm??????????????????????????????????????????????????????????????á????????12?????????????????0.6m?????????????????????????????????7cm?????????????????????????????????????磬?????糤????????????????己?????巨??11-12???1-2??????????????1-2?????????????????20-25cm????3-4????????????б?棬??????紲?????????5-[FS:PAGE]10cm????????????????????????1-2????????????2?????30cm????????巨???????4-6????2??????????????????????15-18cm??С???????????????15cm??15cm???????б????Σ?????????????????????????????????????3-4???11-12??????????1.5-2??m ????1.5-2??m????????60cm????45cm????????????????????????????????????????????

?????? ??????и?????????????2-3?Σ??紺???????????????????1?Ρ???????????????????????????????????????????????????????????80cm?????????γ???????????????????????????????????????????????????????????????????????С?????????????????????????????м????????????????????????

???溦???? ??????ú?????5-6?????????????????1??1??200???????????????5???????????粨??0.2-0.3??????????25????????100??????????????????????溦?к??????7-10??????????????????????????????????????????????3???????????????????????????????Bt???300????????????桢??????????????

???????

??????? ????????λ?????????????Σ????2-5mm?????氵????????????????ж???????????????????????????????????????л????????????л?????????????????????????ζ????????????????????????????????

??????? ????????棺????Σ???????5?????????????1?У?????Σ??????????????????????????????????????????????????????????й??????????????????????????????120-180??m?????????????????????????????????????12-16??m??????4-5?б?????????????Σ????????У????й?????С????????????1??????????????Σ?????????????????У?????????????????????

????????????????????1-9???????62-350??m????????????е?????????????????????????7-14??????????????Σ?????????????????1-5????????????????10-25??m????з??????????????????λ???Σ????35-70??m????????????????????????????????????????λ???Σ??з??????????

?????????

???????-5??8-?????????cis-5??8-tetradecadienic acid??????????????к??????????evodene??????????????????evodol????????????limonin????????к????????evodiamine??????????μ?rutaecarpine??????????????evo-carpine??????????????hydroxyevodiamine?????????????wuchuyine???????????ocimene??????????????evodione?????????????evogin??????????????rutaevin????7-??????????7-car-boxyevodiamine??????????????μ?dihydrorutaecarpine????14-??????????μ?14-formyl rutaecarpine????1-???-2-???-4??1H??-???[1-methyl-2-nonyl-4??1H??-quinolone]??N??N-?????-5-???????????N??N-dimethyl-5-methoxytryptamine????N-????????????????N-methylanthranoylamide???????????synephrine?????????????? ??dehydroevodiamine????????????????evodiamide??????????????????[N-??2-methylaminobenzoyl??tryptamine]??6a-????????-5-??????????6a-acetoxy-5-epi-limonin????6??-????????-5-??????????6??-acetoxy-5-ePi-limonin??????????obacunone???????÷??????jangomolide?????????????????????rutaevine acetate??????????????A??graucin A????12a-????????[FS:PAGE]???12a-hydroxylimonin????12a-?????????????????12a-hydroxyevodol????1-???-2[??Z??-6-????]-4??1H??-?????1-methyl-2[??Z??-6-undecenyl]-4??1H??-quinolone????1-???-2-[??Z??-10-?????]-4??1H??-?????1-methyl-2-[??Z??-10-pentadecenyl]??4??1H??-quinolone????1-???-2-[??Z??-6-?????]??4??1H??-?????1-methyl-2-[??Z??-6-pentadecenyl]??4??1H??-quinolone????1-???-2-[??6Z??9Z??-6??9-???????]-4??1H????????1-methyl-2-[??6Z??9Z??-6??9-pentadecadienyl]??4??1H????quinolone????1-???-2-[??4Z 7Z????4??7-???????]-4??1H??-?????1-methyl-2-[??4Z??7Z??-4??7-tridecadienyl]-4??1H??-quinolone?????????ǹ???????goshuyuamide ????????ǹ???????goshuyuamide ???????????л?????????aspartic acid?????????tryptophan?????????threonine?????????serine???????????cystine??????????????

????????????????????evodin?????????????limonin?????????????????μ???????????????????Shih-Hu A????????????????????????????dihydroevocarpine????1-???-2-?????-4??1H??-???[1-methyl-2-undecyl-4??1H??-quinolone??]??1???-2-[??Z??-6-?????]-4??1H??-?????1-methyl-2-[??Z??-6-undecenyl]-4??1H??-quinolone????

????????á?

1.??????????????????

1.1.??????????

1.1.1.??????????????14???6?????????????????????????100g?????100g????????50g??????????????????1g??ml??????????????????????????????????????????????????8?????????????????????????????????????????????衣?????????????????ü???С??????????????????????????????????????????????????????????

1.1.2.???????3???????1.75??0.09kg?????С?????????????????м????????????е?绻?????????????????????????????????????????????????0.3g??kg?????30?????????????2%????????????????????????????????????????????????30????????????????????????????????????????????30??????δ???????????

1.2.??????????

1.2.1.??3????????????????????????????????????????????????0.2g??kg?????????13.29??5.71??kPa??X??SD???????????????????????????24.36??5.60??????10.79??1.24??P??0.01?????????11.07??5.41??????2.20??0.73??P??0.05??????????368??635????????????????????565??95s??

1.2.2.????9????????????????????????1.04g??kg???????????????????????????????????????????3???????0.04mg??kg?????????????????????????????????????????????????????P??0.001???????????6?????????顣???????????1.8mg??kg???????????????????3.0mg??kg??5????????????????????1.04g??kg???????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????ú???????-????????????????????????????????????????к??????????????Щ??鲢?????????????????????????????á?

1.3.??????????????????

?????11????????????λ??????????????????????????????80???????????????????????????????????????????0.3ml??kg??5????????????????????0.3g??[FS:PAGE]kg?????????????????????????????????????????????????????????????????仯?????????????????????????????????????????????????????????????????

2.?????????????????

2.1.??θ???????????

2.1.1.???????????????????????С??50???????21.2??1.2g???????5?飬???1???????θ??????????????????????????????????????????????????20-23????У???λ??С?????8С?????С???θ????????????????????????????????????2g??kg??50%???????????п?????????????????????????????66.6%??

2.1.2.????????????????????????:?????С??50???????23.4??1.9g???????5?飬???24С??????θ??????????????????????????30??????????????10mg??kg??lС??????θ50%???0.2ml????????lС??????θ????????????????????????mm??????????????????10??20g??kg??????????????????????????????γɡ?

2.1.3.????????θ????????:???????40???????176??21g???????4?飬???24С???????????????????????????????????lС????θ0.6N????1ml????????lС??????θ????????????????????????mm???????????????????8????????5??10g??kg???????????????????γɡ?

2.1.4.??????????????????????????20???????145??16g??????2?飬???24С????????????????????????????????????????????????????????????19С??????θ???????θ????????????????????????8D???????????10g??kg?????????????γ?????

2.2.??θ???????????????240-300g??????????20??????????顣???24С?????????????????鰴10g??kg??????????????????????????2?Σ????м??lС????????????????????????????θ???30???????????????????????????????????????????5h??????????????θ???????????pH???????????????????????????????????????????θ????????????????θ?????

2.3.??θ????????????

2.3.1.???θ??????:????18-22g????С????21????????2?飬??????????????????θ?з???????????????????????θ?в??????????????????????????????????θ???????

2.3.2.????????θ?????:???????θ???????????????????????????????θ???????????仯????????????????????????????????е?ζ???????????5??l0(-3)g/ml??????????????1??10(-2)g/ml?????θ???????????????????????????????????????????????????????????????ζ???Ρ????桢??????θ??????????????????????????????????????θ????????????????ζ?????????????????????????????????????????????????????????????

2.3.3.?????????????????С?????????:????1.5kg?????????250g?????????????????峦????鷨???????飬???????????????????????????????????䴙?????䴙???????䴙???????????????????????鰷?????????????????????????3???????????????1?Σ???3?Σ?????????????????鰷?????????????????????г???3??????????????θ????????3?????????仯?????????????????????????????7???????????С???????????

2.3.4.??????:???????30?????????У?????300-400g????????3?飬???10?????????????????????????????????????????????????????????θ??????????lС???????θ2%?????1ml??100g???????[FS:PAGE]??????????????????????????????????????1С??????????????????????????????????????????????????????????γ???????????????????ζ???????????????????????????????

2.3.5.?к????:??

2.3.5.1.????????????С??к????????С??36???????20.7??2.6g???????3?飬????θ???????????????????30????????????0.15ml??????????к????????????????????????????10g??20g??kg?????????????????к??????????????????????ó????????????????ò?????????

2.3.5.2.???к?????С??к????????С??30???????19.2??1.8g???????3?飬???????????????????????30???????к?0.4g????????к????????8С????????????????к???????к?????????????????????ò????仺?????????????????

3.????????????????????????22??????У?????1.75??0.25kg????Wiggers???????????????????????????????????????????????θ?????????????????????????????????????0.5g??ml??10ml/kg??4?Σ?min??3С????????????????????????????3С???6С??????????????????????????????????????????????????????????????????????????????????????????????????????????????????????3С????????11??11?????????P??0.05??????????????6??11??6h???????7??11?????????????P??0.05???????????1/11???????????????????????????????????????????????????????????????????????????????????????????嶶???????????????????????????????彩???

4.?????γ???????????????Wister????60??????????????185??25g???????6?飬???????????????????????????????????飬??LD50??1??5??1??10??10-20g/kg??θ??????????????????????顣?????1С????????γ????????????????????????飬???????l00u/kg???????????????????????????20g??kg??????????γ???????????????10g??kg??????????????????????????KPTT???в??????????20g/kg???????KPTT??VF??????????????????????仯??

5.???????????CCl4?????????????SGPT??SGOT???????????36???????222??25g??????4?飬??????θl?????????????????????????5????θ????1С????????????????????????????????????????CCl4??0.3ml??kg???????16С?????????????????????????SGPT??SGOT???????????5??10g??kg??????CCl4????SGPT?????????5g??kg?鲻????CCl4????SGOT???á?

6.???????????С???θ20g/kg???????????????????????????????????巴???????????????????????????????????????????????????????5-?????????????????????????????????????5-????????弤????????????????????ǹ??????????????й???????????V-79???????????á????????з??????????????????????V-79???????????????????У???д???????????????????????????????????????????????KB????????????????????????P388????????????????????У????д?????????????????????IC50???????V-79?0.19mg??ml??KB?0.98mg??ml??P388?0.43mg??ml???????????ǹ????????????п???????á?

?????????????? ???????0.5g?????????????l??100??10ml???????????????????????????2ml????????????1?Σ?????????????????????????????????????1ml?????????????????????????2ml[FS:PAGE]?????????????????紦?????????????????????????????????????????????С??????????????????????????Σ???????????????????????????????С?????????????Σ?????????????????????????????????

????????????????????????????????????????????????????????????????ɡ??????????100??????6??4??????

????ζ???????????С??

???????Σ?θ????????????

?????????Ρ???????????????????????????????丹?????????????????????????????????????йк??

???÷??????????????????1.5-5g???????衢???????????????????????????

?????

1.?????????????

2.?????????????????й????ɡ?

3.????????????????????????????????

4.????????衷???????????θ??????????????????????纮??а?????????????????????????????л??????????????????????а?????θ??????????????????????????С????????????к?а?????????????????????????????????θ??????????????????????????θ????????????????????????????????????????????ɡ?

????????????

1.?????????塷???????????????????????????????

2.????????????????????????????????????????ζ?????????????????к???????????????к????????????????????????????

3.???ù????????????????Ｑ?????????????????????????????????????????????????????????θ??????????

4.?????????????????????????????????????????????????????????????У????????????????????????????????????????????????????????????????????????????????У??????????壬??ν??????????в?????????????????????С??????????????????????????????????????????????

5.????????衷?????θ???????????????????????????????????????????????????????????????????淢????????????????????????θ?????а??????????????????????????????????????????а???????纮??а??????θ?????θ???????а?????????????????????????????????????????????????????纮??а???????????????ж??????а?????????θ?????????а???????????

6.???????????????????????????????併???????????????????С?????????????????????????????????????????????????????θ?????йк????????????????????????????????????????С???????????????????????????????????????????????

7.?????????????????????????????????г?????????????????????????????α???????????????????????????????????????????θλ??????????Ч??

8.????????????????????????????????????????????????????θ???????????θ???????????????????????????????????θ????????????????????????????????а???м????????????????????????????????????????????????????????书??????θ???θ????????????????????????